熟女镇
就去色 正高档商议东说念主员
就去色
西西人体艺术摄影王菊仙 有机化学室 商议员 博士生导师
熟谙配景及责任资历:
1997.9-2001.7 江苏省徐州师范大学化学系 本科
2001.9-2004.7江苏省徐州师范大学化学系 硕士
2005.8-2008.7 北京协和医学院医药生物技能商议所 博士
2008.9-于今 北京协和医学院医药生物技能商议所就去色
主要商议观念:药死亡学,有机化学
专科商议限制:抗感染药物代谢详尽征药物的缱绻合成及构效关系商议,药物先导物、候选物的发现
代表性论文:
1、Guoning Zhang, Minghua Wang, Jianyuan Zhao, Yujia Wang, Mei Zhu, Juxian Wang,Shan Cen, Yucheng Wang, Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NHacetamide moieties at C-4, European Journal of Medicinal Chemistry (2020) 206, 112706.
2、Na Zhang, Shuang-shuang Zhao, Yi-xuan Zhang, Yu-cheng Wang, Rong-guang Shao, Ju-xian Wang & Hong-wei He, A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression, Acta Pharmacologica Sinica (2020) 41, 661–669.
3、Jinfeng Ren, Jian Xu, Guoning Zhang, Changliang Xu, Lili Zhao, Xuefu You, Yucheng Wang, Yu Lu, Liyan Yu, Juxian Wang, Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents, Bioorganic & Medicinal Chemistry Letters (2019) 29, 539–543.
4、Mao-xu Ge, Wei-xiao Niu, Jin-feng Ren, Shi-ying Cai, Dong-ke Yu, Hong-tao Liu, Na Zhang, Yi-xuan Zhang, Yu-cheng Wang, Rong-guang Shao, Ju-xian Wang, Hong-wei He, A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters , Acta Pharmacologica Sinica. (2019) 40, 895–907.
5、Liu Hongtao, Pang Guoxun, Ren Jinfen, Zhao Yue, Wang Juxian, A novel class of apical sodium--dependent bile salt transporter inhibitors: 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides, Acta Pharm Sin B. 2017, 7(2),223-229.
专利:
1、王周密 朱梅 王菊仙 张国宁 董飚 彭宗根 岑山 王宇佳 杜潇楠 王明华 赵跃 李云鸽 张煊笛 邵端阳 牛伟萍, 一种酰胺类繁衍物或其药学上可接管的盐过头制备设施和垄断, CN201810493926.7
2、王周密 张国宁 王菊仙 李强 白晓光 游雪甫 李子强 周磊 朱梅 任金凤 赵越,新式锌离子螯合剂过头制备和在抗革兰氏阴性菌感染中的垄断,201610115005.
干系电话:010-63131053
电子邮箱:wangjuxian@imb.pumc.edu.cn就去色